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Ucla researchers have developed an implantable device that acts like a “charging station” for cancer-fighting immune cells, helping them stay active for longer and attack tumours more effectively.
Detailed in Nature Biomedical Engineering, the platform is designed to support CAR-iNKT cells, which has shown potential against both solid tumours and blood cancers but often loses strength after entering the body.
The device uses biomimetic microparticles implanted near a tumour to attract these cells and reactivate them with localised signals. Researchers said it could improve future cancer immunotherapies.
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